blaOXA-10,efflux pump and aminoglycoside resistance genes in Pseudomonas aeruginosa from Nigeria

Aminoglycoside resistance in Pseudomonas aeruginosa.

In vitro characterization of aminoglycoside adaptive resistance in Pseudomonas aeruginosa.

Aminoglycoside adaptive resistance was characterized in one reference strain and four clinical isolates of Pseudomonas aeruginosa. Adaptive resistance was initiated with a 2-h gentamicin or tobramycin exposure at the MIC. Each P. aeruginosa strain demonstrated an adaptive-resistance period of between 8 and 12 h when tested with both aminoglycosides. Aminoglycoside adaptive resistance was shown ...

Antibiotic resistance profiles of Pseudomonas aeruginosa isolates containing virulence genes

Background: A most common opportunistic pathogen, Pseudomonas aeruginosa is present in both humans and animals and responsible for various nosocomial infections and healthcare settings related infections. Different virulence genes like; oprL (membrane lipoprotein L) and toxA (exotoxin A i.e. ETA) in P. aeruginosa, assist in its pathogenicity, toxicity and contribute to high antibiotic resistanc...

Lability of Resistance to Aminoglycoside Antibiotics in Pseudomonas Aeruginosa

The determinants for resistance to aminoglycoside antibiotics in some strains of Pseudomonas aeruginosa were irreversively lost during storage or by treatment with ethidium bromide. This fact has indicated the presence of plasmids governing resistance to aminoglycosides in the pseudomonads as well as R factor in gram-negative enteric bacteria and plasmid in staphylococci. Many papers have descr...

Genome-Scale Identification Method Applied to Find Cryptic Aminoglycoside Resistance Genes in Pseudomonas aeruginosa

BACKGROUND The ability of bacteria to rapidly evolve resistance to antibiotics is a critical public health problem. Resistance leads to increased disease severity and death rates, as well as imposes pressure towards the discovery and development of new antibiotic therapies. Improving understanding of the evolution and genetic basis of resistance is a fundamental goal in the field of microbiolog...